Product Introduction

Pancreatinase is a mixture of several digestive enzymes produced by the exocrine cells of the pancreas, encompassing amylase, lipase, and protease enzymes. These enzymes facilitate the digestion of carbohydrates, fats, and proteins, respectively [1]. Pancreatinase is derived from porcine or bovine pancreas. It is used to address conditions of pancreatic insufficiency [2]. The activity of pancreatinase is defined by the amount of each enzyme present, typically measured in units according to pharmacopeial standards.

Production Process

The production of pancreatinase involves several key steps: extraction, purification, and standardization. The pancreas glands are collected from livestock animals, and enzymes are extracted using a series of aqueous solutions and filtration techniques [3]. The extracted material undergoes purification to remove unwanted components, such as non-enzymatic proteins and lipids. The enzyme mixture is then standardized by adjusting the concentration of each enzyme (amylase, lipase, and protease) to meet specific activity requirements. Finally, the standardized pancreatinase is dried, often using lyophilization or spray drying, to create a stable powder [4].

Product Effects and Benefits

Pancreatinase primarily supports digestion by supplementing the body's natural enzymes. It aids in breaking down complex carbohydrates into simpler sugars, fats into fatty acids and glycerol, and proteins into amino acids [5]. This enzyme supplementation can alleviate symptoms associated with pancreatic insufficiency, such as malabsorption, steatorrhea (fatty stools), and abdominal discomfort [6]. It improves nutrient absorption. It supports overall digestive health, particularly in individuals with compromised pancreatic function.

Product Applications

Pancreatinase finds applications across several industries due to its enzymatic properties:

  • Pharmaceuticals: Used in medications to treat exocrine pancreatic insufficiency (EPI) caused by conditions like cystic fibrosis, chronic pancreatitis, and pancreatic cancer [7].
  • Digestive Aids: Included in over-the-counter digestive supplements to help break down food and alleviate bloating or indigestion [8].
  • Food Industry: Employed in food processing to modify starches, proteins, and fats, enhancing the texture and digestibility of certain food products [9].
  • Animal Feed: Added to animal feed to improve nutrient utilization in livestock, particularly in young animals or those with digestive disorders.

Packaging and Storage

Pancreatinase is typically packaged in airtight containers to protect it from moisture and light, which can degrade the enzymes. Common packaging materials include sealed plastic containers, glass bottles, and foil-lined bags.
Storage conditions are critical to maintaining the enzyme activity and shelf life. It should be stored in a cool, dry place, ideally between 2°C to 8°C (36°F to 46°F), to minimize enzyme degradation [10]. Exposure to high temperatures and humidity should be avoided. Proper packaging and storage help ensure the product remains effective over its intended shelf life.

Citations:

[1] Whitcomb, D. C. (2010). Pancreatitis. Digestive Diseases and Sciences, 55(12), 3214–3226.
[2] Singh, V. K., et al. (2017). Chronic Pancreatitis: Challenges and Progress. Gastroenterology, 152(7), 1775-1788.
[3] Röcken, C., & Kruger, S. (2003). Morphology and Function of the Human Exocrine Pancreas. Pancreatology, 3(4), 269-278.
[4] Layer, P., et al. (1986). Enzyme Replacement Therapy of Exocrine Pancreatic Insufficiency: Comparative Effects of Different Enzyme Preparations. Pancreas, 1(5), 469-475.
[5] Dominguez-Munoz, J. E. (2011). Pancreatic enzyme therapy for exocrine pancreatic insufficiency: what to use, when, and how. Current Gastroenterology Reports, 13(5), 428–434.
[6] Carrière, F., et al. (2011). Contribution of Gastric Lipase to Human Dietary Fat Digestion. Reproduction Nutrition Development, 40(6), 621-632.
[7] Gubergrits, N., et al. (2011). Enzyme Therapy for Pancreatic Insufficiency. World Journal of Gastroenterology, 17(45), 4981.
[8] Ianiro, G., et al. (2016). Digestive Enzyme Supplementation in Gastrointestinal Diseases. Current Drug Metabolism, 17(2), 187-193.
[9] Otles, S., & Cagindi, O. (2003). Functional Properties of Food Enzymes. Journal of Functional Foods, 4(2), 221-234.
[10] Fujifilm Diosynth Biotechnologies. (n.d.). Enzyme Storage Conditions. Retrieved from [https://www.fujifilmdiosynth.com/fileadmin/imported/pdf/Enzyme_Storage_Conditions.pdf]

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