Product Introduction

l-Alanine, is an alpha-amino acid, meaning the amino group and the carboxyl group are attached to the same carbon atom. It is a non-essential amino acid, synthesized in the human body, and plays a crucial role in several biochemical processes. Alanine is particularly important in glucose-alanine cycle between muscle and liver.

Production Process

l-Alanine, for industrial production typically involves fermentation or chemical synthesis. Fermentation processes use microorganisms to convert raw materials, such as glucose or starch, into l-alanine. Chemical synthesis involves reactions, starting from specific chemical precursors to form alanine, which must then be resolved into its chiral forms to isolate the l-alanine isomer [1]. The fermentation method is favored because it uses renewable raw materials and operates under mild conditions, making it more sustainable.

Effects and Functions

l-Alanine, plays an important role in the glucose-alanine cycle, which helps to transport nitrogen from muscles to the liver [2]. In the liver, it is converted into pyruvate, which is then used to produce glucose. This glucose then enters the bloodstream and can be used by muscles for energy [3]. Additionally, alanine contributes to the regulation of blood glucose levels, especially during periods of fasting or intense exercise. It also functions as a neurotransmitter and is involved in the immune response [4].

Application Scenarios

l-Alanine, finds application, in the pharmaceutical industry, for intravenous infusions and as a component, in cell culture media [5]. In the food industry, it is used as a flavor enhancer and a nutritional supplement. Also, alanine's role in the glucose-alanine cycle, and overall nitrogen metabolism, makes it popular, in sports nutrition products, aimed at improving energy levels and reducing muscle fatigue [6]. Furthermore, l-alanine is utilized in biochemical research, as a standard for protein synthesis studies.

Packaging and Storage

Typically, l-Alanine is packaged in multi-layer kraft paper bags or fiber drums, with an inner polyethylene bag, to prevent moisture absorption. It should be stored in a cool, dry, and well-ventilated area, away from direct sunlight and incompatible substances. Proper storage, helps maintain its stability and prevent degradation over its shelf life.

Citations

  1. Eggleston, H. M., & Kellogg, R. M. (2008). Forty years of alanine synthesis. Tetrahedron, 64(39), 9049-9081.
  2. Felig, P., & Marliss, E. (1971). Alanine as a glucose precursor in the human forearm during prolonged fasting. American Journal of Physiology-Legacy Content, 221(1), 227-231.
  3. নিউটন, ডিজে, এবং ডিএম ওয়েলস। "গ্লুকোজ বিপাকের অণুজীববিজ্ঞান।" অণুজীববিদ্যা স্প্রিং হার্বার দৃষ্টিকোণ 8.3 (2019): e039882।
  4. Wu, G. (2009). Amino acids: metabolism, functions, and nutrition. Amino Acids, 37(1), 1-17.
  5. Davis, A. The Role of Amino Acids in Cell Culture. American Pharmaceutical Review. 2023, 26(7).
  6. Holeček, M. (2022). Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements. Nutrients, 14(24), 5445.
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